Articles
  • Sol-gel synthesis and apatite-formation ability of nanostructure merwinite (Ca3MgSi2O8) as a novel bioceramic 
  • Masoud Hafezi-Ardakania, Fatollah Moztarzadeha,*, Mohammad Rabieea,*, Ali Reza Talebib, Marziye Abasi-shahnic, Farzaneh Fesahatb and Fatemeh Sadeghianb
  • a Biomaterial Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, Tehran, Iran b Research and Clinical Center for Infertility, and Department of Anatomy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran c Biomedical Engineering Faculty, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract
The need to improve synthetic materials for human bone replacement is significant. Nanostructured bioceramics are expected to have better bioactivity than microcrystals. Merwinite (Ca3MgSi2O8) ceramic is a new bioceramic with good biocompatibility. The aim of this study was the preparation, characterization and evaluation of the bioactivity of nanostructured merwinite. Nanostructured merwinite was synthesized by a sot-gel process. Evaluation of the bioactivity was preformed by immersing the nanostructured merwinite in a simulated body fluid (SBF) and the formation of apatite on the surface of the immersed nanostructured merwinite was investigated. The results showed that hydroxyapatite (HAp) was formed after soaking for 7 days. Osteoblast viability and proliferation was measured by a cell proliferation kit I (MTT). Our study indicated that nanostructured merwinite possessed an apatite-formation ability, show a good bioactivity and might be used for preparation of new biomaterials.

Keywords: Merwinite; Sol-gel synthesis; Bioceramics; Simulated body fluid; Hydroxyapatite

This Article

  • 2010; 11(6): 765-768

    Published on Dec 31, 2010