Articles
  • Preparation of a nano-hydroxyapatite/chitosan/konjac glucomannan composite as a novel degradable drug delivery system
  • Gang Zhoua,b,c, Yu-Bao Lic and Soo-Wohn Leea,*
  • a Department of Materials Engineering, Sun Moon University, Asan, Chungnam 336-708, Korea b College of Chemistry, Sichuan University, Chengdu 610064, China c Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, China
Abstract
A Nano-hydroxyapatite (n-HA)/chitosan (CS)/konjac glucomannan (KGM) composite was prepared by integrating composition and molding. Then, X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) were used to analyze the physical, chemical and degradable properties of the composite before and after immersion in simulated body fluid (SBF). Moreover, an in vitro test for drug delivery revealed that the amount of released pentoxifylline (1-[5-oxohexyl]-3, 7-dimethylxanthine)(PTX) reached a plateau and equaled 80% of the drug loaded in an implant. The newly developed n-HA/CS/KGM composite may serve as a good degradable biomaterial for an implantable drug delivery system (IDDS) in bone tissue engineering.

Keywords: n-HA/CS/KGM composite, In vitro test, Degradability, Drug delivery.

This Article

  • 2008; 9(4): 353-357

    Published on Aug 31, 2008