Mg-Al-based alloys have grown in popularity as possible biomaterials for various biological purposes due to their ability to degrade and biocompatibility. For biological conditions, the resistance of corrosion magnesium alloys is still an issue. By altering the surface of the Mg-2Al-1Nd alloy, MgF₂ coatings were created using the ultrasonically treated fluoride method (UHF) to decrease the rate of biocorrosion and cytotoxicity. The coating was approximately 488.1 nm thick, on average. According to the results of cytotoxicity, after 48 hours of culture, the growth of MC3T3-E1cells and L929cells were widely distributed on MgF₂ coated Mg-2Al-1Nd alloy surface; a small number of cells were observed on the uncoated alloy samples, but the MgF₂ film coating demonstrated the alloy’s minimal cytotoxicity and excellent biocompatibility. In summary, fluorite chemical conversion coating has shown benefits on the Mg-2Al-1Nd alloy’s enhanced cell responsiveness. It should be a helpful technique for modifying the surface of various magnesium alloys used in biomedical applications.

Keywords: Mg alloys, Ceramic Coating, Cytotoxicity, Biomaterials, Biomedical applications.