Articles
  • Boron nitride nanostructures reinforced nanohydroxyapatite: bifunctional nanocomposite for potential orthopedical use and ciprofloxacin controlled delivery

  • Luísa Arantes Fernandes Vieira, Isabela Barreto da Costa Januário Meireles and Edésia Martins Barros Sousa

  • Comissão Nacional de Energia Nuclear – Centro de Desenvolvimento da Tecnologia nuclear – (CNEN/CDTN), Laboratório de Materiais Nanoestruturados para Bioaplicações, Av. Presidente Antônio Carlos 6.627, Pampulha, 31270-901, Belo Horizonte, MG, Brazil

  • This article is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

One of the most promising options for bone defects or lesions is the use of synthetic materials as bone substitutes. Thus, the objective of the present work was to synthesize a nanocomposite of HA and BNNS, as a reinforcement phase, to obtain a material with satisfactory mechanical properties as well as bifunctional, with the incorporation of ciprofloxacin to evaluate the potential of the system as a drug delivery. The nanocomposites obtained were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG), nitrogen adsorption by BET and BJH methods, scanning electron microscopy (SEM) and electron microscopy transmission (TEM). The Vickers hardness test and nanoindentation showed an increase in the mechanical strength of the nanocomposites with the insertion of the reinforcement phase, thus corroborating the promising character of BNNS as a reinforcement agent for HA. A biocompatibility assay was performed to assess the potential of the samples as effective biomaterials. The nanocomposites showed high cell viability indicating that the system does not present cytotoxicity. Drug loading and in vitro release show that the system can provide rapid drug delivery, giving antibacterial effects at the infected site, indicating that the nanocomposite, a bioceramic, is suitable for the application


Keywords: Hydroxyapatite, Boron nitride nanosheets, Reinforcement, Bone repair

This Article

  • 2022; 23(5): 725-736

    Published on Oct 31, 2022

  • 10.36410/jcpr.2022.23.5.725
  • Received on May 17, 2022
  • Revised on Jun 14, 2022
  • Accepted on Jun 8, 2022

Correspondence to

  • Edésia Martins Barros Sousa

  • Comissão Nacional de Energia Nuclear – Centro de Desenvolvimento da Tecnologia nuclear – (CNEN/CDTN), Laboratório de Materiais Nanoestruturados para Bioaplicações, Av. Presidente Antônio Carlos 6.627, Pampulha, 31270-901, Belo Horizonte, MG, Brazil
    Tel : +55-31-3439-9523

  • E-mail: sousaem@cdtn.br