Articles
  • Nitrilotriacetic acid functionalization on Fe3O4 nanoparticle via amino and carboxylic functionalization

  • Jin Soon Hana,**, MiRae Youma,**, Hyun-Hee Choib, Yeon-Gil Jungb, Sung-Churl Choia and Gye Seok Ana,*

  • aHanyang university 04763 Division of Materials Science and Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Republic of Korea
    bSchool of Materials Science and Engineering, Changwon National University, 20 Changwondaehak-ro, Changwon, Gyeongnam 51140, Republic of Korea

Abstract

Since chelating chemical had focused for enhancing bio-susceptibility and ability for the binding with biomaterials, in this study, Nitrilotiriacetic acid (NTA) was utilized for the developing chelate ligand attached superparamagnetic nanoparticle. In order to conjugate NTA, carboxylic group was needed on the surface of substrate particle for building peptide bond with amine group which was branched from the NTA structure. Therefore Fe3O4 nanoparticle was functionalized with various of amine precursor (Polyethyleneimine (PEI), (3-Aminopropyl)triethoxysilane (APTES)), and carboxyl precursor (Polyacrylic acid (PAA)) before the conjugation of NTA. Then NTA conjugation behavior was estimated which is varied with the type of amine precursor which affects to the surface properties.


Keywords: Magnetic nanoparticle, Chelate ligand, Nitilotriacetic acid, Functionalization

This Article

  • 2020; 21(5): 515-523

    Published on Oct 31, 2020

  • 10.36410/jcpr.2020.21.5.515
  • Received on Feb 3, 2020
  • Revised on Mar 31, 2020
  • Accepted on Apr 7, 2020

Correspondence to

  • Gye Seok An

  • Hanyang university 04763 Division of Materials Science and Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Republic of Korea
    Tel : +8222200505
    Fax: +8222916767

  • E-mail: faustmaro@hanyang.ac.kr